For tangled lopunny puffs, you’ll need a detangling spray, a pin brush, and a wide-toothed comb. You may also wish to use a dematting comb, but it really depends on your preference and how badly tangled her puffs are.
If her puffs are thoroughly matted, use the detangling spray first and then go through with either the dematting comb or your fingers to untangle as much of the puff by hand. Go easy and take your time; these puffs are very sensitive to a lopunny. If the puffs aren’t too badly tangled, you may wish to simply spray the puffs and use the pin brush and comb instead. Use your best judgment, but either way, finish off with the pin brush, followed by the comb. Also, never pull your lopunny’s fur; instead, hold the fur you wish to work with between two fingers of one hand and use the brushes and comb with your other. This will keep you from accidentally pulling your lopunny’s ears.
Afterwards, give her a treat as always for good behavior. Also, don’t forget to groom your lopunny’s puffs regularly to avoid future tangles and to use a good grooming powder to keep your lopunny’s hair in peak condition.
Note: If the above doesn’t work, also remember that a good pokémon groomer should have plenty of experience with grooming lopunny as well. It may be the pricier option, but it’s a viable one.